AMINO-ACID-SEQUENCE OF A SNAKE-VENOM TOXIN THAT BINDS TO THE MUSCARINIC ACETYLCHOLINE-RECEPTOR

被引：42

作者：

KARLSSON, E

RISINGER, C

JOLKKONEN, M

WERNSTEDT, C

ADEM, A

机构：

[1] BIOMED CTR,LUDWIG INST CANC RES,S-75123 UPPSALA,SWEDEN

[2] KAROLINSKA INST,HUDDINGE HOSP,INST GERIATR MED,S-14186 HUDDINGE,SWEDEN

来源：

TOXICON | 1991年 / 29卷 / 4-5期

关键词：

D O I：

10.1016/0041-0101(91)90027-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The green mamba, Dendroaspis angusticeps, has two protein toxins that bind to the muscarinic acetylcholine receptor. The sequence of muscarinic toxin 2 was determined with an automatic gas phase sequencer. The C-terminal residue is Asp as determined by hydrazinolysis and amino acid analysis. Toxin 2 has 65 amino acid residues and a formula weight of 7040. It is homologous to a large number of other snake venom toxins as short alpha-neurotoxins, cardiotoxins/cytotoxins and angusticeps-type toxins of mamba venoms. The sequence is confirmed in the accompanying article (DUCANCEL, F., ROWAN, E. G., CASSART, E., HARVEY, A. L., MENEZ, A. and BOULAIN, J.-C. Toxicon 29, 516-520, 1991).

引用

页码：521 / 526

页数：6

共 25 条

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