LIPID PEROXIDE LEVELS IN DIABETICS WITH MICRO-ANGIOPATHIES AND MACRO-ANGIOPATHIES

This study examined lipid peroxides and lipid profile in diabetics with and without complications. One hundred seventeen non-insulin dependent diabetics and 34 insulin dependent diabetics were compared with healthy controls. All diabetics had poor glycemic control. Dyslipidemia was observed in diabetics, with the highest value being recorded in diabetics with complications. Lipid peroxide values were elevated in diabetics as compared with healthy controls, The highest values were found in patients with complications. Peroxides showed a negative but significant correlation with high density lipoproteins-cholesterol fraction. Lipid peroxide values were significantly influenced by age of the patient, duration of diabetes, age at onset of diabetes, body mass index, and duration of ischemic heart disease. These results indicate that increased peroxidative stress may be an important risk factor in the development of microangiopathy and macroangiopathy.