HIGH-DOSES OF GONADOTROPINS HAVE NO DETRIMENTAL EFFECT ON IN-VITRO FERTILIZATION OUTCOME IN NORMAL RESPONDERS

被引：9

作者：

SIMON, T ^{[1
]}

JONES, D ^{[1
]}

OEHNINGER, S ^{[1
]}

MUASHER, S ^{[1
]}

TONER, J ^{[1
]}

机构：

[1] EASTERN VIRGINIA MED SCH,JONES INST REPROD MED,DEPT OBSTET & GYNECOL,NORFOLK,VA 23507

来源：

FERTILITY AND STERILITY | 1995年 / 63卷 / 06期

关键词：

GONADOTROPINS; GNRH-A; IVF; PREGNANCY RATE;

D O I：

10.1016/S0015-0282(16)57621-3

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders. Design: Retrospective analysis of patients undergoing IVF therapy from 1990 to 1994 at our institution. Setting: Academic tertiary center. Patients: A homogeneous group of women that consisted of intermediate responders examined in their initial attempt and who received differing amounts of gonadotropins were examined. Interventions: All patients were stimulated using a combination of a GnRH-agonist and FSH and hMG and were allocated into two groups, based on the amount of gonadotropin administered initially (four or six ampules). Main Outcome Measures: Implantation and pregnancy (clinical and ongoing) rates were compared. Results: There were no significant differences between patients receiving high doses versus those patients receiving lower doses of gonadotropins with regard to implantation and pregnancy rates. Conclusions: We conclude that high doses of gonadotropins have no detrimental effect on IVF outcome in normal (intermediate) responders.

引用

页码：1333 / 1336

页数：4

共 5 条

[1]

Manzi D.L., Thorton K.L., Scott L.B., Nulsen J.C., The value of increasing the dose of human menopausal gonadotropins in women who initially demonstrate a poor response, Fertil Steril, 62, pp. 251-256, (1994)

[2]

Stadtmauer L., Ditkoff E.C., Session D., Kelly A., High dosages of gonadotropins are associated with poor pregnancy outcomes after in vitro fertilization-embryo transfer, Fertil Steril, 61, pp. 1058-1064, (1994)

[3]

Muasher S.J., Use of gonadotropin-releasing hormone agonists in controlled ovarian hyperstimulation for in vitro fertilisation, Clin Ther, 14, Suppl A, pp. 74-86, (1992)

[4]

Toner J.P., Philput C.B., Jones G.S., Muasher S.J., Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age, Fertil Steril, 55, pp. 784-791, (1991)

[5]

Grow D.D., Oehninger S., Seltman H.J., Toner J.P., Swanson R.J., Kruger T.F., Et al., Sperm morphology as diagnosed by strict criteria: probing the impact of teratozoospermia on fertilization rate and pregnancy outcome in a large in vitro fertilization population, Fertil Steril, 62, pp. 559-567, (1994)

← 1 →