LAPAROSCOPIC COLON SURGERY IN A RAT MODEL - A PRELIMINARY-REPORT

被引：22

作者：

BERGUER, R

GUTT, CN

机构：

[1] Department of Surgery, The University of California Davis Medical Center, Sacramento, 95817, CA

[2] Johann-Wolfgang-Goethe Universitat Frankfurt, Frankfurt, 60590

来源：

SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES | 1994年 / 8卷 / 10期

关键词：

LAPAROSCOPY; RATS; COLON; INTESTINAL ANASTOMOSIS; ANIMAL MODEL;

D O I：

10.1007/BF00591049

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The effects of laparoscopic colectomy on immune function require further study. Because the rat has been widely used to investigate the immune system we studied the feasibility of laparoscopic sutured colon anastomoses in a rat model. We used a low-pressure CO2 pneumoperitoneum, a 2.7-mm 30-degrees-wide-angle arthroscope and video system, and microotologic forceps and scissors to perform two-handed dissection and suturing of the rat colon. The procedures included laparoscopic division of the colon and colostomy (group A, n = 3), laparoscopic closure of a colotomy (group B, n = 4), and complete laparoscopic division and reanastomosis of the colon (group C, n = 4). One anesthetic death occurred in group C. Necropsy performed 1-15 days postoperatively revealed no anastomotic leaks and two anastomotic strictures. Laparoscopic sutured colon anastomosis in the rat is feasible and may provide a new model for the physiologic study of laparoscopic colon surgery.

引用

页码：1195 / 1197

页数：3

共 20 条

[1] Berguer R., Gutt C.N., Stiegmann G.V., Laparoscopic surgery in the rat: description of a new technique, Surg Endosc, 7, pp. 345-347, (1993)
[2] Berkenbosch F., Wolvers D.A., Derijk R., Neuroendocrine and immunological mechanisms in stress-induced immunomodulation, J Steroid Biochem Mol Biol, 40, pp. 639-647, (1991)
[3] Cooper G.M., Scoggins A.M., Ward I.D., Murphy D., Laparoscopy: a stressful procedure, Anaesthesia, 37, pp. 266-269, (1982)
[4] Falk P.M., Beart R., Wexner S.D., Thorson A.G., Jagelman D.G., Lavery I.C., Johansen O.B., Fitzgibbons R., Laparoscopic colectomy: a critical appraisal, Dis Colon Rectum, 36, pp. 28-34, (1993)
[5] Filmar S., Gomel V., McComb P.F., Operative laparoscopy versus open abdominal surgery: a comparative study on post-operative adhesion formation in the rat model, Fertil Steril, 48, pp. 486-489, (1987)
[6] Flecknell P.A., Laboratory animal anesthesia, (1987)
[7] Garcia-Caballero M., Vara-Thorbeck C., The evolution of postoperative ileus after laparoscopic cholecystectomy: a comparative study with conventional cholecystectomy and sympathetic blockade treatment, Surg Endosc, 7, pp. 416-419, (1993)
[8] Griffith J., Everitt N., Curley P., McMahon M., Laparoscopic versus “open” cholecystectomy—reduced influence upon immune function and the acute phase response, Surg Endosc, 7, (1993)
[9] Harmon G., Senagore A., Kilbride M., Luchtefeld M., MacKeigan J., Warzynski M., Cortisol and IL-6 response attenuated following laparoscopic colectomy, Surg Endosc, 7, (1993)
[10] Hill A.D.K., Banwell P.E., Querechi A., Menzies-Gow N., Darzi A., Monson J.R.T., Guillou P.J., IL-6 response in laparoscopic versus open herniorrhaphy, Surg Endosc, 7, (1993)

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