REAPPRAISAL OF THYROXINE TREATMENT IN PRIMARY HYPOTHYROIDISM

被引：6

作者：

HODGES, S

OMALLEY, BP

NORTHOVER, BN

WOODS, KL

SWIFT, PGF

机构：

[1] UNIV LEICESTER,DEPT CHILD HLTH,LEICESTER LE1 7RH,ENGLAND

[2] UNIV LEICESTER,DEPT PHARMACOL & THERAPEUT,LEICESTER LE1 7RH,ENGLAND

[3] CITY LEICESTER POLYTECH,DEPT PHARMACOL,LEICESTER LE1 9BH,ENGLAND

[4] LEICESTER GEN HOSP,DEPT PAEDIAT,LEICESTER,ENGLAND

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1990年 / 65卷 / 10期

关键词：

D O I：

10.1136/adc.65.10.1129

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The optimum dialy dose of thyroxine was calculated for 13 children aged 3-16 years with primary hypothyroidism by titrating their doses at monthly intervals. The condition of the thyroid was assessed by sensitive assay of thyroid stimulating hormone concentrations, as well as measurement of total and free thyroid hormone concentrations and systolic time interval ratios. Serum thyroid stimulating hormone concentration was found to be the most responsive to small changes in thyroxine. The calculated optimum daily replacement dose of thyroxine (102 μg/m2 or 3.5 μg/kg) was fractionally lower than that previously recommended, and was more closely related to surface area (coefficient of variation 8.2%) than to body weight (coefficient of variation 16.2%). Our result suggest that though monthly may be the optimal time interval for increases in the dose of thyroxine, any reduction in the dose should be made more gradually.

引用

页码：1129 / 1132

页数：4

共 13 条

[1]

[Anonymous], 1959, RADIOGRAPH ATLAS SKE

[2]

DUSSAULT JH, 1988, NEONATAL THYROID SCR, P271

[3] REPLACEMENT DOSE, METABOLISM, AND BIOAVAILABILITY OF LEVOTHYROXINE IN THE TREATMENT OF HYPOTHYROIDISM - ROLE OF TRIIODOTHYRONINE IN PITUITARY FEEDBACK IN HUMANS [J].