SUPPRESSOR T-CELLS IN MYASTHENIA-GRAVIS AND ANTIBODIES TO ACETYLCHOLINE-RECEPTOR

被引：17

作者：

LISAK, RP

LARAMORE, C

LEVINSON, AI

ZWEIMAN, B

MOSKOVITZ, AR

机构：

[1] UNIV PENN, SCH MED, DEPT NEUROL, PHILADELPHIA, PA 19104 USA

[2] UNIV PENN, SCH MED, DEPT MED, ALLERGY & IMMUNOL SECT, PHILADELPHIA, PA 19104 USA

[3] HENRY M WATTS JR NEUROMUSCULAR RES CTR, PHILADELPHIA, PA 19104 USA

来源：

ANNALS OF NEUROLOGY | 1986年 / 19卷 / 01期

关键词：

D O I：

10.1002/ana.410190119

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We cultured blood mononuclear cells of patients with myasthenia gravis both with and without removal of T8 suppressor cells. The levels of synthesized antibodies to acetylcholine receptor and IgG as well as the frequency of immunoglobulin-secreting cells were all higher in pokeweek mitogen-stimulated cultures depleted of T8+ cells. Thus, autologous suppressor cells within the T8+ population exert some regulatory control over antiacetylcholine receptor-producing cells in patients with myasthenia gravis.

引用

页码：87 / 89

页数：3

共 12 条

[1]

ERSTILER WB, 1983, CLIN IMMUNOL, V26, P10

[2]

KEIGHTLEY RG, 1976, J IMMUNOL, V117, P1538

[3] ANALYSIS OF B-CELL ACTIVATION OF CEREBROSPINAL-FLUID LYMPHOCYTES IN MULTIPLE-SCLEROSIS [J].