EFFECT OF TRANSFORMING GROWTH-FACTOR-BETA AND BASIC FIBROBLAST GROWTH-FACTOR ON STEROID-IMPAIRED HEALING INTESTINAL WOUNDS

被引：34

作者：

SLAVIN, J

NASH, JR

KINGSNORTH, AN

机构：

[1] UNIV LIVERPOOL,DEPT SURG,POB 147,LIVERPOOL L69 3BX,ENGLAND

[2] UNIV LIVERPOOL,DEPT PATHOL,LIVERPOOL L69 3BX,ENGLAND

来源：

BRITISH JOURNAL OF SURGERY | 1992年 / 79卷 / 01期

关键词：

D O I：

10.1002/bjs.1800790124

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A longitudinal intestinal wound model in the pig was used to assess the effect of parenteral steroids (betamethasone 12 mg 50 kg-1 intramuscularly twice daily) on breaking load. Steroid treatment significantly decreased the breaking load of wounds in the ileum and colon in comparison with wounds from saline-treated animals. In a further group of animals receiving steroids, paired longitudinal wounds were constructed. One wound of a pair was treated with a local application of transforming growth factor beta (TGF-beta) (5-mu-g per wound) or basic fibroblast growth factor (5-mu-g per wound) in a collagen suspension. The other wound was treated with a collagen suspension alone. Ileal wounds treated with TGF-beta were significantly stronger than collagen-treated controls at 7 days. The steroid-induced impairment of breaking load in intestinal wounds is partially reversed by a local application of TGF-beta in a collagen suspension at the time of surgery.

引用

页码：69 / 72

页数：4

共 39 条

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[2]

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