SYNTHESIS OF 6,7-DIHYDRO-8-(4-METHYL-1-PIPERAZINYL)-[1]BENZOXEPINO[4,5-C]QUINOLINE AS POTENTIAL 5-HT3 RECEPTOR-LIGAND

被引：6

作者：

ANZINI, M

CAPPELLI, A

VOMERO, S

机构：

[1] Dipartimento Farmaco Chimico Tecnologico - Università di Siena - Banchi di Sotto

来源：

HETEROCYCLES | 1993年 / 36卷 / 05期

关键词：

D O I：

10.3987/COM-92-6276

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two synthetic routes to the achievement of the title compound are described. The [1]benzoxepino[4,5-c]quinoline nucleus was prepared by nucleophilic aromatic fluoride displacement-cyclization and functionalized with N-methylpiperazine moiety. Alternatively the oxepino ring closure is shifted as the final step. An oxepine ring cleavage occurred in compounds (9) and (3); a mechanistical interpretation is proposed.

引用

页码：1065 / 1074

页数：10