PALLADIUM-CATALYZED SYNTHESIS OF NEW UNSATURATED EXO-ENOL LACTONES WITH POTENTIAL BIOLOGICAL-ACTIVITY

被引：45

作者：

BOUYSSI, D ^{[1
]}

GORE, J ^{[1
]}

BALME, G ^{[1
]}

LOUIS, D ^{[1
]}

WALLACH, J ^{[1
]}

机构：

[1] UNIV LYON 1,CNRS,BIOCHIM ANALYT LAB,F-69622 VILLEURBANNE,FRANCE

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)93397-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various allenenols lactones [5(E)-(2-allenylidene)-tetrahydro-2-furanones] have been synthesized by reacting 4-pentynoic acid and 2-alkynyl acetate in dimethyl sulfoxide in the presence of K2CO3, Pd(OAc)2 as the catalyst and tri(2-furyl) phosphine as the ligand. The biological activity of these compounds as protease inhibitors has been proven.

引用

页码：3129 / 3130

页数：2

共 18 条

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