ENHANCEMENT OF MEMORY RETRIEVAL AND ATTENUATION OF SCOPOLAMINE-INDUCED AMNESIA FOLLOWING ADMINISTRATION OF 5-HT3 ANTAGONIST ICS-205-930

Experimental evidence suggests an important role of serotonin in the process of learning and memory. The present study investigated the effect of 5HT3-receptor antagonist (ICS 205-930) on retrieval of a previously learned aversive habit in the mouse. The effect of ICS 205-930 on scopolamine (3 mg/kg) induced amnesia was also studied. ICS 205-930 (1, 10 & 100-mu-g/kg) produced a dose-dependent increase in latency to cross into the dark chamber. The scopolamine induced memory impairment was significantly attenuated by ICS 205-930 (10-mu-g/kg). These results suggest that memory deficits may be susceptible to attenuation with non-cholinergic treatments.