GROWTH-FACTORS AND BLADDER-CANCER - CLINICAL IMPLICATIONS OF THE INTERACTIONS BETWEEN GROWTH-FACTORS AND THEIR UROTHELIAL RECEPTORS

被引：35

作者：

MESSING, EM ^{[1
]}

机构：

[1] UNIV WISCONSIN,DIV UROL & HUMAN ONCOL,MADISON,WI 53706

来源：

SEMINARS IN SURGICAL ONCOLOGY | 1992年 / 8卷 / 05期

关键词：

EPIDERMAL GROWTH FACTOR; RECEPTORS; GROWTH FACTORS;

D O I：

10.1002/ssu.2980080507

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Growth factors (GFs) are a class of proteins that bind to specific cell surface receptors (GF-Rs), inducing a variety of responses including mitosis, in susceptible target cells. Abnormal production, expression, and/or function of GFs or GF-Rs can result in unregulated growth, the hallmark of malignant transformation. This chapter reviews those GFs/GF-Rs that have been linked to human bladder cancer. It focuses particularly on one [epidermal growth factor (EGF), which is excreted in urine in high concentrations] and its possible role in the development and growth of urothelial malignancy. Potential clinical applications in diagnosis, staging, prevention, and treatment are discussed.

引用

页码：285 / 292

页数：8

共 51 条

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