MEASUREMENT OF EUMELANIN PRECURSOR METABOLITES IN THE URINE AS A NEW MARKER FOR MELANOMA METASTASES

被引：23

作者：

YAMADA, K ^{[1
]}

WALSH, N ^{[1
]}

HARA, H ^{[1
]}

JIMBOW, K ^{[1
]}

HUA, C ^{[1
]}

ITO, S ^{[1
]}

机构：

[1] UNIV ALBERTA,FAC MED,DIV DERMATOL & CUTANEOUS SCI,HERITAGE MED RES CTR 260G,EDMONTON T6G 2S2,ALBERTA,CANADA

来源：

ARCHIVES OF DERMATOLOGY | 1992年 / 128卷 / 04期

关键词：

D O I：

10.1001/archderm.128.4.491

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background and Design.- This article introduces a rapid high-performance liquid chromatographic assay to measure urinary pheomelanin and eumelanin metabolites, 5-S-cysteinyldopa and indoles, 5(6)-hydroxy-6(5)-methoxyindole-2-carboxylic acid. Results.- Our high-performance liquid chromatographic study clearly showed (1) urine of melanoma patients with positive metastasis revealed significant amounts of 5-S-cysteinyldopa and indoles (5,6-dihydroxyindole-2-carboxylic acid plus 6-hydroxy-5-methoxyindole-2-carboxylic acid) above 1-mu-mol/d and 2-mu-mol/d, respectively; and (2) in patients with metastasis-free melanoma these melanin metabolites might be excreted into the urine but always less than the two values cited above. Conclusions.- As there is a discrepancy regarding the specificity of 5-S-cysteinyldopa as a marker for estimation of melanoma metastasis, high-performance liquid chromatographic measurement of urinary indoles will provide an additional assay in the detection of melanoma metastasis from an early stage. Both melanoma markers were increased in the urine of patients with metastatic melanoma.

引用

页码：491 / 494

页数：4

共 22 条

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