CEREBROSPINAL-FLUID APOLIPOPROTEIN-E IS REDUCED IN ALZHEIMERS-DISEASE

被引:88
作者
BLENNOW, K
HESSE, C
FREDMAN, P
机构
[1] Department of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of GÖteborg, Molndal
关键词
ALZHEIMERS DISEASE; APOLIPOPROTEIN E; CEREBROSPINAL FLUID;
D O I
10.1097/00001756-199412000-00032
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
APOLIPOPROTEIN E (ApoE) has been implicated in the pathogenesis of Alzheimer's disease (AD). ApoE is synthesized within the brain and has been suggested to be involved in the re-utilization of membrane lipids during neuronal repair and remyelination after injury. Spherical ApoE-containing lipoprotein particles are found in the cerebrospinal fluid (CSF). To study further the pathogenetic role of ApoE in degenerative brain disorders, we analysed ApoE in CSF. A significant (p < 0.001) reduction of CSF ApoE (1.5 +/- 1.2 ng ml(-1)) was found in AD compared with controls (5.0 +/- 2.7 ng ml(-1)). A less pronounced reduction was also found in frontal lobe dementia (3.1 +/- 1.5 ng ml(-1); p < 0.05). These findings support the hypothesis that ApoE is involved in the pathogenesis of degenerative brain disorders such as AD. An increased reutilization of ApoE-lipid complexes in the brain, as part of a generalized repair process, may explain the low CSF ApoE in AD. Alternatively, the reduction of CSF ApoE may be caused by absorption of ApoE to senile plaques and neurofibrillary tangles.
引用
收藏
页码:2534 / 2536
页数:3
相关论文
共 23 条
  • [1] PROTEIN ANALYSES IN CEREBROSPINAL-FLUID .1. INFLUENCE OF CONCENTRATION GRADIENTS FOR PROTEINS ON CEREBROSPINAL-FLUID SERUM-ALBUMIN RATIO
    BLENNOW, K
    FREDMAN, P
    WALLIN, A
    GOTTFRIES, CG
    LANGSTROM, G
    SVENNERHOLM, L
    [J]. EUROPEAN NEUROLOGY, 1993, 33 (02) : 126 - 128
  • [2] APOLIPOPROTEIN-E ASSOCIATED WITH ASTROCYTIC GLIA OF THE CENTRAL NERVOUS-SYSTEM AND WITH NONMYELINATING GLIA OF THE PERIPHERAL NERVOUS-SYSTEM
    BOYLES, JK
    PITAS, RE
    WILSON, E
    MAHLEY, RW
    TAYLOR, JM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (04) : 1501 - 1513
  • [3] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES
    CORDER, EH
    SAUNDERS, AM
    STRITTMATTER, WJ
    SCHMECHEL, DE
    GASKELL, PC
    SMALL, GW
    ROSES, AD
    HAINES, JL
    PERICAKVANCE, MA
    [J]. SCIENCE, 1993, 261 (5123) : 921 - 923
  • [4] ASSOCIATION OF APOLIPOPROTEIN-E E4 WITH VASCULAR DEMENTIA
    FRISONI, GB
    BIANCHETTI, A
    GOVONI, S
    TRABUCCHI, M
    CALABRESI, L
    FRANCESCHINI, G
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (17): : 1317 - 1317
  • [5] ABNORMAL PHOSPHORYLATION OF THE MICROTUBULE-ASSOCIATED PROTEIN-TAU (TAU) IN ALZHEIMER CYTOSKELETAL PATHOLOGY
    GRUNDKEIQBAL, I
    IQBAL, K
    TUNG, YC
    QUINLAN, M
    WISNIEWSKI, HM
    BINDER, LI
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) : 4913 - 4917
  • [7] HESSE C, 1994, UNPUB
  • [8] LIPOPROTEIN UPTAKE BY NEURONAL GROWTH CONES INVITRO
    IGNATIUS, MJ
    SHOOTER, EM
    PITAS, RE
    MAHLEY, RW
    [J]. SCIENCE, 1987, 236 (4804) : 959 - 962
  • [9] APOLIPOPROTEIN-E - CHOLESTEROL TRANSPORT PROTEIN WITH EXPANDING ROLE IN CELL BIOLOGY
    MAHLEY, RW
    [J]. SCIENCE, 1988, 240 (4852) : 622 - 630
  • [10] MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939