TETRODOTOXIN-SENSITIVE ACTION-POTENTIALS IN SMOOTH-MUSCLE OF MOUSE VAS-DEFERENS

被引：8

作者：

HOLMAN, ME

TONTA, MA

PARKINGTON, HC

COLEMAN, HA

机构：

[1] Department of Physiology, Monash University, Clayton

来源：

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1995年 / 52卷 / 2-3期

关键词：

SMOOTH MUSCLE; SODIUM CHANNEL; NEUROTRANSMISSION; EXCITABILITY; ACTION POTENTIAL;

D O I：

10.1016/0165-1838(94)00157-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Action potentials were recorded during impalements of some but not all smooth muscle cells of mouse vas deferens in response to both nerve stimulation and intracellular current injection. They were resistant to blockade by nifedipine (0.1-1.0 mu M) but were blocked by tetrodotoxin (TTX, 0.2-1.0 mu M) when this was added in the presence of nifedipine. It is suggested that voltage-dependent sodium (Na+) channels are present in mouse vas deferens that function to amplify calcium (Ca2+) influx through voltage-dependent Ca2+ channels.

引用

页码：237 / 240

页数：4

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