NONRANDOM CHROMOSOME CHANGES IN MULTIPLE-SCLEROSIS

被引：11

作者：

DALESSANDRO, E ^{[1
]}

DICOLA, M ^{[1
]}

LORE, ML ^{[1
]}

LIGAS, C ^{[1
]}

VACCARELLA, C ^{[1
]}

DANDREA, F ^{[1
]}

MARINI, C ^{[1
]}

PRENCIPE, M ^{[1
]}

机构：

[1] UNIV LAQUILA,DIPARTIMENTO MED INTERNA & SANITA PUBBL,NEUROL CLIN,I-67100 LAQUILA,ITALY

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1990年 / 37卷 / 03期

关键词：

chromosomal changes; preferential breakpoints; premature centromere division;

D O I：

10.1002/ajmg.1320370322

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In order to study the role of genetic factors in multiple sclerosis, cytogenetic analysis was performed on 48 patients with the clinically defined disease. We found a high incidence of subjects (50%) with abnormal chromosomes, showing premature centromere division of the X chromosome and structural aberrations, translocations, or deletions that could suggest preferential breakpoints. Correlation between clinical and cytogenetic data showed that cytogenetic abnormalities were more common in patients with high frequency of relapse or with a progressive form of the disease.

引用

页码：406 / 411

页数：6

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