EFFECTS OF SIMVASTATIN AND PRAVASTATIN ON 6-BETA-HYDROXYCORTISOL EXCRETION, A POTENTIAL MARKER OF CYTOCHROME-P-450-3A

被引：25

作者：

HORSMANS, Y

DESAGER, JP

VANDENBERGE, V

ABRASSART, M

HARVENGT, C

机构：

[1] Laboratoire de Pharmacothérapie, Université Catholique de Louvain, B-1200 Bruxelles

来源：

PHARMACOLOGICAL RESEARCH | 1993年 / 28卷 / 03期

关键词：

PRAVASTATIN; SIMVASTATIN; 6-BETA-OH CORTISOL; CYTOCHROME-P-450-3A; CAUCASIAN SUBJECTS;

D O I：

10.1006/phrs.1993.1127

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of two inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, simvastatin and pravastatin, on the level of urinary 6β-hydroxycortisol/17-hydroxycorticosteroids (6β-OHC/17-OHCS) ratio was determined in two groups of normolipidemic Caucasian subjects (n=18 and n=14, respectively). The 6β-OHC/17-OHCS ratio increased significantly after simvastatin administration (20 mg day-1 for 17 days) (P=0.0125) whereas no modification was observed after pravastatin administration (20 mg day-1 during 17 days). As the level of 6β-OHC/17-OHCS ratio is a function of cytochrome P-450 3A activity, these results suggest that in Caucasian subjects, simvastatin but not pravastatin could be a weak inducer of cytochrome P-450 3A. This contrasting effect could be related to the major pharmacological differences existing between these two drugs. © 1993 The Italian Pharmacological Society.

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页码：243 / 248

页数：6

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