TRANSFORMATION OF CONGENITAL NEUTROPENIA INTO MONOSOMY-7 AND ACUTE NONLYMPHOBLASTIC LEUKEMIA IN A CHILD TREATED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR

被引：36

作者：

WEINBLATT, ME

SCIMECA, P

JAMESHERRY, A

SAHDEV, I

KOCHEN, J

机构：

来源：

JOURNAL OF PEDIATRICS | 1995年 / 126卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(95)70557-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A cytogenetically normal infant with Kostmann syndrome (severe congenital granulocytopenia) was treated with granulocyte colony-stimulating factor, which resulted in a rapid improvement in his neutrophil count and a resolution of recurrent infections, After 11 months of therapy, splenomegaly developed, with thrombocytopenia, anemia, circulating nucleated erythrocytes, and acquired monosomy 7, which evolved during a period of 7 months into acute nonlymphoblastic leukemia, The use of granulocyte colony-stimulating factor in patients with congenital marrow failure disorders may induce or hasten the onset of a malignant transformation.

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页码：263 / 265

页数：3

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