SYNTHESIS OF 3-ALKYLPYRIDINES .2. SYNTHESIS OF BOTH ENANTIOMERS OF NIPHATESINE-C

被引：15

作者：

BRACHER, F

PAPKE, T

机构：

[1] Institut für Pharmazeutische Chemie, Technische Universität Braunschweig, 38106 Braunschweig

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 18期

关键词：

D O I：

10.1039/p19950002323

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both enantiomers of the pyridine alkaloid niphatesine C 1 have been prepared in a convergent synthesis by acylation of the nonracemic thiophenes 3 and ent-3, reductive desulfurization, and functional group transformation. The absolute configuration of the natural product was established as (S) based on comparison of the sense of optical rotation with that of synthetic 1.

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页码：2323 / 2326

页数：4

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