EARLY REPLICATION BLOCK OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN MONKEY CELLS

被引：115

作者：

SHIBATA, R ^{[1
]}

SAKAI, H ^{[1
]}

KAWAMURA, M ^{[1
]}

TOKUNAGA, K ^{[1
]}

ADACHI, A ^{[1
]}

机构：

[1] KYOTO UNIV,INST VIRUS RES,DEPT VIRAL ONCOL,GENE ANAL LAB,KYOTO 606,JAPAN

来源：

JOURNAL OF GENERAL VIROLOGY | 1995年 / 76卷

关键词：

D O I：

10.1099/0022-1317-76-11-2723

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The genetic and functional basis of the replication-defective nature of human immunodeficiency virus type 1 (HIV-1) in monkey cells was studied. By the generation and characterization of chimeras between HIV-1 and simian immunodeficiency virus, the sequence encompassing the 3' half of the long terminal repeat, gag and pol genes of HIV-1 was found to be responsible for the growth restriction. Early and late phases of HIV-1 replication in monkey cells were analysed in detail using several assay systems: transfection/coculture, transcomplementation between various proviral clones carrying the CAT gene and effector clones and evaluation of transcription and reverse transcription. All the data were consistent with the notion that HIV-1 replication is blocked at a very early stage(s) such as uncoating and/or reverse transcription in monkey cells.

引用

页码：2723 / 2730

页数：8

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