BLACK-WHITE DIFFERENCES IN SERUM-LIPOPROTEINS DURING SEXUAL-MATURATION - THE BOGALUSA HEART-STUDY

被引:33
作者
FREEDMAN, DS
SRINIVASAN, SR
WEBBER, LS
BURKE, GL
BERENSON, GS
机构
[1] LOUISIANA STATE UNIV, MED CTR, NATL RES & DEMONSTRAT CTR ARTERIOSCLEROSIS, 1542 TULANE AVE, NEW ORLEANS, LA 70112 USA
[2] LOUISIANA STATE UNIV, MED CTR, DEPT MED, NEW ORLEANS, LA 70112 USA
[3] LOUISIANA STATE UNIV, MED CTR, DEPT PUBL HLTH & PREVENT MED, NEW ORLEANS, LA 70112 USA
[4] LOUISIANA STATE UNIV, MED CTR, DEPT BIOCHEM, NEW ORLEANS, LA 70112 USA
[5] LOUISIANA STATE UNIV, MED CTR, DEPT BIOMETRY & GENET, NEW ORLEANS, LA 70112 USA
来源
JOURNAL OF CHRONIC DISEASES | 1987年 / 40卷 / 04期
关键词
D O I
10.1016/0021-9681(87)90046-4
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Serum lipid, lipoprotein cholesterol, and apolipoprotein (A-I and B) levels were compared between 940 and black and 1710 white children who were between the ages of 5 and 17 years. Stratification, matching, and analysis of covariance were used to determine whether black-white differences in levels of serum triglycerides (TG), very low- (VLDL-C), and high- (HDL-C) density lipoprotein cholesterol, and apolipoprotein A-I (apoA-I) could be explained by differences in sexual maturation, obesity, cigarette smoking, alcohol intake, oral contraceptive use, insulin, and glucose. Independently of these covariates, blacks had elevated levels of HDL-C and apoA-I (males only), and whites had increased levels of TG and VLDL-C. All differences were statistically significant at the 0.001 level. In addition, racial contrasts tended to be greater in sexually mature, as compared with prepubertal, males; a similar divergence of levels with sexual maturation was not observed in females. HDL-C levels in white males were partially explained (R2 = 0.12) by sexual maturation, insulin, and obesity; apoA-I levels were associated with only sexual maturation and insulin. Racial differences in levels of serum lipids, lipoprotein cholesterol, and apoA-I in early life, therefore, exist independently of differences in several lipoprotein determinants. Since the initial stages of atherosclerosis begin in the young, these black-white lipoprotein contrasts may influence differences in adult coronary heart disease rates between the races.
引用
收藏
页码:309 / 318
页数:10
相关论文
共 35 条
[1]  
Berenson G.S., 1986, CAUSATION CARDIOVASC
[2]   DYNAMIC CHANGES OF SERUM-LIPOPROTEINS IN CHILDREN DURING ADOLESCENCE AND SEXUAL-MATURATION [J].
BERENSON, GS ;
SRINIVASAN, SR ;
CRESANTA, JL ;
FOSTER, TA ;
WEBBER, LS .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1981, 113 (02) :157-170
[3]   FASTING PLASMA-GLUCOSE AND INSULIN LEVELS AND THEIR RELATIONSHIP TO CARDIOVASCULAR RISK-FACTORS IN CHILDREN - BOGALUSA HEART-STUDY [J].
BURKE, GL ;
WEBBER, LS ;
SRINIVASAN, SR ;
RADHAKRISHNAMURTHY, B ;
FREEDMAN, DS ;
BERENSON, GS .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1986, 35 (05) :441-446
[4]   CORONARY-ARTERY DISEASE IN BLACKS - RISK-FACTORS [J].
CURRY, CL ;
OLIVER, J ;
MUMTAZ, FB .
AMERICAN HEART JOURNAL, 1984, 108 (03) :653-657
[5]  
DALFERES ER, 1980, CLIN CHEM, V26, P493
[6]   LIPIDS AND LIPOPROTEINS IN A YOUNG-ADULT POPULATION - THE BEAVER COUNTY LIPID STUDY [J].
DONAHUE, RP ;
ORCHARD, TJ ;
KULLER, LH ;
DRASH, AL .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1985, 122 (03) :458-467
[7]   ANTHROPOMETRIC AND MATURATION MEASUREMENTS OF CHILDREN, AGES 5 TO 14 YEARS, IN A BIRACIAL COMMUNITY - BOGALUSA HEART STUDY [J].
FOSTER, TA ;
VOORS, AW ;
WEBBER, LS ;
FRERICHS, RR ;
BERENSON, GS .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1977, 30 (04) :582-591
[8]   RELATIONSHIP OF CHANGES IN OBESITY TO SERUM-LIPID AND LIPOPROTEIN CHANGES IN CHILDHOOD AND ADOLESCENCE [J].
FREEDMAN, DS ;
BURKE, GL ;
HARSHA, DW ;
SRINIVASAN, SR ;
CRESANTA, JL ;
WEBBER, LS ;
BERENSON, GS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 254 (04) :515-520
[9]   LONGITUDINAL SERUM LIPOPROTEIN CHANGES IN WHITE MALES DURING ADOLESCENCE - THE BOGALUSA HEART-STUDY [J].
FREEDMAN, DS ;
CRESANTA, JL ;
SRINIVASAN, SR ;
WEBBER, LS ;
BERENSON, GS .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1985, 34 (04) :396-403
[10]   SERUM-LIPIDS AND LIPOPROTEINS AT BIRTH IN A BIRACIAL POPULATION - BOGALUSA HEART STUDY [J].
FRERICHS, RR ;
SRINIVASAN, SR ;
WEBBER, LS ;
RIETH, MC ;
BERENSON, GS .
PEDIATRIC RESEARCH, 1978, 12 (08) :858-863