STEM-CELLS AND T AND B LYMPHOCYTES DURING TUMOR-GROWTH

被引：15

作者：

KHAITOV, RM ^{[1
]}

PETROV, RV ^{[1
]}

GAMBAROV, SS ^{[1
]}

NORIMOV, AS ^{[1
]}

BLINOV, VA ^{[1
]}

机构：

[1] MINIST HLTH, BIOPHYS INST, MOSCOW, USSR

来源：

CELLULAR IMMUNOLOGY | 1976年 / 22卷 / 01期

关键词：

D O I：

10.1016/0008-8749(76)90001-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Functional activities of T and B lymphocytes and the kinetics of hematopoietic stem cells were studied in mice with inoculated or spontaneous tumors. The development and growth of the tumor inhibited B cells and helper T cells, while the activity of killer T cells and spleen suppressor cells was markedly enhanced. The processes of stem cell migration from the bone marrow were considerably intensified and altered in tumor-bearing mice. Helper T cells and killer T cells may represent nonidentical compartments within the population of thymus-dependent lymphocytes. Immunosuppression during tumor bearing is probably due to an impairment of T lymphocytes cooperating in immune responses, B-lymphocytes and their precursors.

引用

页码：1 / 10

页数：10

共 24 条

[1]

BIANO G, 1971, P SOC EXP BIOL MED, V136, P507

[2]

Feldman M, 1972, Transplant Rev, V12, P57

[3] CHANGES IN HOMING PROPERTIES OF LABELED LYMPHOID-CELLS CAUSED BY SOLID TUMOR-GROWTH [J].

GILLETTE, RW ;

BOONE, CW .

CELLULAR IMMUNOLOGY, 1974, 12 (03) :363-369

[4]

GUNTNER D, 1974, NATURE, V249, P358

[5]

HRSAK I, 1973, PERIOD BIOL, V75, P251

[6] PLAQUE FORMATION IN AGAR BY SINGLE ANTIBODY-PRODUCING CELLS [J].

JERNE, NK ;

NORDIN, AA .

SCIENCE, 1963, 140 (356) :405-&

[7]

KAMO I, 1971, GANN, V62, P453

[8]

Katz D H, 1972, Adv Immunol, V15, P1, DOI 10.1016/S0065-2776(08)60683-5

[9]

KHAITOV RM, 1972, GENERAL PROBLEMS PAT

[10]

KONDA S, 1973, CANCER RES, V33, P2247

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