REQUIREMENT FOR COTOLEROGENIC GENE-PRODUCTS IN THE CLONAL DELETION OF I-E REACTIVE T-CELLS

被引:236
作者
WOODLAND, D
HAPP, MP
BILL, J
PALMER, E
机构
[1] NATL JEWISH CTR IMMUNOL & RESP MED, DIV BASIC SCI, DENVER, CO 80206 USA
[2] UNIV COLORADO, HLTH SCI CTR, DEPT MICROBIOL & IMMUNOL, DENVER, CO 80262 USA
关键词
D O I
10.1126/science.1968289
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
T cells that express the T cell receptor Vβ5.2 domain react with the class II major histocompatibility complex (MHC) molecule I-E, and Vβ5.2+ T cells are deleted in mouse strains that express I-E glycoproteins. By examination of genetically defined recombinant inbred (RI) mouse strains, it was found that the deletion was dependent on the expression of I-E and one of a limited number of non-MHC gene products (cotolerogens). The gene encoding one ofthese cotolerogens maps to chromosome 12 and is linked to the endogenous provirus Mtv-9. These observations suggest that the IE-mediated and minor lymphocyte-stimulating antigen (Mls)-mediated deletions of αβ T cells from the repertoire are similar; both require the expression of a class II MHC glycoprotein and a second non-MHC gene product.
引用
收藏
页码:964 / 967
页数:4
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