MAPPING OF BOVINE MARKERS CYP21, PRL, AND BOLA DRBP1 BY GENETIC-LINKAGE ANALYSIS IN REFERENCE PEDIGREES

被引：20

作者：

CREIGHTON, P

EGGEN, A

FRIES, R

JORDAN, SA

HETZEL, J

CUNNINGHAM, EP

HUMPHRIES, P

机构：

[1] SWISS FED INST TECHNOL,ZUCHTUNGSBIOL GRP,INST NUTZTIERWISSENSCH,CH-8092 ZURICH,SWITZERLAND

[2] UNIV QUEENSLAND,CTR MOLEC GENET,ST LUCIA,QLD 4072,AUSTRALIA

来源：

GENOMICS | 1992年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0888-7543(05)80260-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have analyzed DNA from 13 bovine reference pedigrees using primers specific for microsatellite markers derived from the 21-steroid hydroxylase (CYP21) and prolactin (PRL) genes and the leukocyte antigen (BOLA DRBP1) pseudogene. Linkage was demonstrated between PRL and BOLA DRBP1 (θ{symbol} = 0.05; Z = 19.6), cyp21 and PRL (θ{symbol} = 0.13; Z = 6.8), and BOLA DRBP1 and CYP21 (θ{symbol} = 0.17; Z = 10.4). These results suggest an order BOLA DRBP1-PRL-CYP21, although in a multilocus analysis the alternative order PRL-BOLA DRBP1-CYP21 was also possible. The data confirm and extend the previously established syntenic relationship between these markers on bovine chromosome 23 and provide points of anchorage for further linkage studies in the reference pedigrees described. © 1992 Academic Press, Inc. All rights reserved.

引用

页码：526 / 528

页数：3

共 17 条

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