HAZARD ASSESSMENT OF LEAD

被引：25

作者：

CARRINGTON, CD

SHEEHAN, DM

BOLGER, PM

机构：

[1] Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, 20204

[2] Food and Drug Administration, Jefferson, AR, 72079, National Center for Toxicological Research

来源：

FOOD ADDITIVES AND CONTAMINANTS | 1993年 / 10卷 / 03期

关键词：

LEAD; TOLERABLE INTAKE;

D O I：

10.1080/02652039309374155

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Exposure to lead (Pb) continues to be a source of concern for the US Food and Drug Administration and other United States federal regulatory agencies. Blood lead levels as low as 10 mug/dl have been associated with impaired neurobehavioural and cognitive development and electrophysiological deficits in children and reduced gestational age and birth weight in infants. Blood lead levels of 10 mug Pb/dl are also of concern in pregnant women because of exposure to the fetus. Blood lead levels of 30 mug Pb/dl have been associated with elevated blood pressure and other adverse effects in adults. Thus, the values of 10 and 30 mug Pb/dl represent lowest-observed-effects levels for developing and adult populations, respectively. The ingestion levels that result in these blood levels of concern were estimated to be 60 mug Pb/day for children ages 6 years or younger, 150 mug Pb/day for children aged 7 years or older, 250 mug Pb/day for pregnant women and 750 mug Pb/day for adults. Provisional total tolerable intake levels for lead were derived from these blood lead levels for each group by applying the Renwick approach to obtain a tolerable exposure level.

引用

页码：325 / 335

页数：11

共 26 条

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