IMMUNOCHARACTERIZATION OF H-2K(B)-TSA58 TRANSGENIC MOUSE HIPPOCAMPAL NEUROEPITHELIAL CELLS

被引：22

作者：

KERSHAW, TR ^{[1
]}

RASHIDDOUBELL, F ^{[1
]}

SINDEN, JD ^{[1
]}

机构：

[1] INST PSYCHIAT,DEPT PSYCHOL,LONDON SE5 8AF,ENGLAND

来源：

NEUROREPORT | 1994年 / 5卷 / 16期

基金：

英国惠康基金;

关键词：

PROLIFERATION; BASIC FIBROBLAST GROWTH FACTOR; CONDITIONAL IMMORTALIZATION; HIPPOCAMPAL PRECURSOR CELLS; NEURONAL DIFFERENTIATION;

D O I：

10.1097/00001756-199410270-00052

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

FROM dissected fragments of embryonic H-2K(b)-tsA58 transgenic mouse hippocampal neuroepithelium, we have derived a population of rapidly proliferating, nestin-positive conditionally immortal hippocampal neuroepithelial cells. Treatment with dibutyryl cAMP in non-permissive culture conditions resulted in cessation of cell division and differentiation of the precursor cells into neuronal or glial phenotypes.

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收藏

页码：2197 / 2200

页数：4

相关论文

共 9 条

[1] THE CHARACTERIZATION OF ASTROCYTE CELL-LINES THAT DISPLAY PROPERTIES OF GLIAL SCAR TISSUE [J].

GROVES, AK ;

ENTWISTLE, A ;

JAT, PS ;

NOBLE, M .

DEVELOPMENTAL BIOLOGY, 1993, 159 (01) :87-104

[2] DIRECT DERIVATION OF CONDITIONALLY IMMORTAL CELL-LINES FROM AN H-2KB-TSA58 TRANSGENIC MOUSE [J].

JAT, PS ;

NOBLE, MD ;

ATALIOTIS, P ;

TANAKA, Y ;

YANNOUTSOS, N ;

LARSEN, L ;

KIOUSSIS, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) :5096-5100

[3] CNS STEM-CELLS EXPRESS A NEW CLASS OF INTERMEDIATE FILAMENT PROTEIN [J].

LENDAHL, U ;

ZIMMERMAN, LB ;

MCKAY, RDG .

CELL, 1990, 60 (04) :585-595

[4] NEURON SPECIFIC ENOLASE, A CLINICALLY USEFUL MARKER FOR NEURONS AND NEUROENDOCRINE CELLS [J].

MARANGOS, PJ ;

SCHMECHEL, DE .

ANNUAL REVIEW OF NEUROSCIENCE, 1987, 10 :269-295

[5] DEVELOPMENT OF NEURON-SPECIFIC ENOLASE IMMUNOREACTIVITY IN AVIAN NERVOUS-TISSUE INVIVO AND INVITRO [J].

MAXWELL, GD ;

WHITEHEAD, MC ;

CONNOLLY, SM ;

MARANGOS, PJ .

DEVELOPMENTAL BRAIN RESEARCH, 1982, 3 (03) :401-418

[6]

NOBLE M, 1992, BRAIN PATHOL, V2, P39

[7] PROLIFERATION, DIFFERENTIATION, AND LONG-TERM CULTURE OF PRIMARY HIPPOCAMPAL-NEURONS [J].

RAY, J ;

PETERSON, DA ;

SCHINSTINE, M ;

GAGE, FH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3602-3606

[8] A MULTIPOTENT EGF-RESPONSIVE STRIATAL EMBRYONIC PROGENITOR-CELL PRODUCES NEURONS AND ASTROCYTES [J].

REYNOLDS, BA ;

TETZLAFF, W ;

WEISS, S .

JOURNAL OF NEUROSCIENCE, 1992, 12 (11) :4565-4574

[9] ESTABLISHMENT OF CONDITIONALLY IMMORTALIZED EPITHELIAL-CELL LINES FROM BOTH COLON AND SMALL-INTESTINE OF ADULT H-2KB-TSA58 TRANSGENIC MICE [J].

WHITEHEAD, RH ;

VANEEDEN, PE ;

NOBLE, MD ;

ATALIOTIS, P ;

JAT, PS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :587-591