THE MAILLARD REACTION INVIVO

被引：79

作者：

DYER, DG ^{[1
]}

BLACKLEDGE, JA ^{[1
]}

KATZ, BM ^{[1
]}

HULL, CJ ^{[1
]}

ADKISSON, HD ^{[1
]}

THORPE, SR ^{[1
]}

LYONS, TJ ^{[1
]}

BAYNES, JW ^{[1
]}

机构：

[1] UNIV S CAROLINA,DEPT CHEM,COLUMBIA,SC 29208

来源：

ZEITSCHRIFT FUR ERNAHRUNGSWISSENSCHAFT | 1991年 / 30卷 / 01期

关键词：

ADVANCED GLYCOSYLATION ENDPRODUCTS (AGE); AG(E)ING; AMINOGUANIDINE; ASCORBATE; AUTOXIDATION; BIOMARKER; BROWNING REACTION; CHEMICAL MODIFICATION OF PROTEINS; DIABETES; GLYCATION; GLYCOXIDATION; NONENZYMATIC GLYCOSYLATION; OXIDATION; MAILLARD REACTION;

D O I：

10.1007/BF01910730

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The Maillard or browning reaction between reducing sugars and protein contributes to the chemical deterioration and loss of nutritional value of proteins during food processing and storage. This article presents and discusses evidence that the Maillard reaction is also involved in the chemical aging of long-lived proteins in human tissues. While the concentration of the Amadori adduct of glucose to lens protein and skin collagen is relatively constant with age, products of sequential glycation and oxidation of protein, termed glycoxidation products, accumulate in these long-lived proteins with advancing age and at an accelerated rate in diabetes. Among these products are the chemically modified amino acids, N-epsilon-(carboxymethyl)lysine (CML), N-epsilon-(carboxymethyl)hydroxylysine (CMhL), and the fluorescent crosslink, pentosidine. While these glycoxidation products are present at only trace levels in tissue proteins, there is strong evidence for the presence of other browning products which remain to be characterized. Mechanisms for detoxifying reactive intermediates in the Maillard reaction and catabolism of extensively browned proteins are also discussed, along with recent approaches for therapeutic modulation of advanced stages of the Maillard reaction.

引用

页码：29 / 45

页数：17

共 35 条

[1]

Feeney R.E., Blankenhorn G., Dixon H.B.F., Adv Prot Chem, 29, pp. 135-203, (1975)

[2]

Lyons T.J., Thorpe S.R., Baynes J.W., Glucose Metabolism, Diabetes and the Vascular Wall, (1991)

[3]

Dunn J.A., Patrick J.S., Thorpe S.R., Baynes J.W., Biochem, 28, pp. 9464-9468, (1989)

[4]

Patrick J.S., Thorpe S.R., Baynes J.W., J Gerontol, 45, (1990)

[5]

Harding J.J., Crabbe M.J.C., The Eye, Vol 1B, pp. 207-492, (1984)

[6]

Ahmed M.U., Thorpe S.R., Baynes J.W., J Biol Chem, 261, pp. 4889-4894, (1986)

[7]

Baynes J.W., Watkins N.G., Fisher C.I., Hull C.J., Patrick J.S., Ahmed M.U., Dunn J.A., Thorpe S.R., The Maillard Reaction in Aging, Diabetes and Nutrition, pp. 43-67, (1989)

[8]

Ledl F., Beck J., Sengl M., Osiander H., Estendorfer S., Severin T., Huber B., The Maillard Reaction in Aging, Diabetes and Nutrition, pp. 23-42, (1989)

[9]

Kato H., Hayase F., Shin D.B., Oimomi M., Baba S., The Maillard Reaction in Aging, Diabetes and Nutrition, pp. 68-83, (1989)

[10]

Oimomi M., Maeda Y., Baba S., Iga T., Yamamoto M., Exp Eye Res, 49, pp. 317-320, (1989)

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