HIMASTATIN, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS .1. TAXONOMY OF PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY

被引：53

作者：

LAM, KS ^{[1
]}

HESLER, GA ^{[1
]}

MATTEI, JM ^{[1
]}

MAMBER, SW ^{[1
]}

FORENZA, S ^{[1
]}

TOMITA, K ^{[1
]}

机构：

[1] BRISTOL MYERS RES INST, TOKYO RES CTR, MEGURO KU, TOKYO 153, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 08期

关键词：

D O I：

10.7164/antibiotics.43.956

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Strain C39108-P210-51 (ATCC 53653), an actinomycete isolated from a soil sample collected in India, was found to produce a new antitumor antibiotic, designated himastatin. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Streptomyces hygroscopicus C39108-P210-51. Himastatin shows antimicrobial activity against Gram-positive bacteria but it is inactive against Gram-negative bacteria. Himastatin prolongs the life span of mice inoculated with P388 leukemia and B16 melanoma cells. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：956 / 960

页数：5

共 8 条

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