HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF AMBROXOL IN HUMAN PLASMA

被引：35

作者：

NOBILIS, M ^{[1
]}

PASTERA, J ^{[1
]}

SVOBODA, D ^{[1
]}

KVETINA, J ^{[1
]}

MACEK, K ^{[1
]}

机构：

[1] FAC HOSP HRADEC KRALOVE, CS-50036 HRADEC KRALOVE, CZECHOSLOVAKIA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 581卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80278-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ambroxol has been determined in biological fluids using a rapid and sensitive high-performance liquid chromatographic method. The samples prepared from plasma by liquid-liquid extraction were analysed on reversed-phase silica gel by competing-ion chromatography with ultraviolet detection. The method was applied to the determination of ambroxol levels in twelve healthy volunteers after oral administration of 90 mg of ambroxol in tablets of Mucosolvan and Ambrosan.

引用

页码：251 / 255

页数：5

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