MINIGLUCAGON PRODUCTION FROM GLUCAGON - AN EXTRACELLULAR PROCESSING OF A HORMONE USED AS A PROHORMONE

被引：6

作者：

BLACHE, P

KERVRAN, A

LENGUYEN, D

BATAILLE, D

机构：

[1] INSERM U 376, CCIPE, 34094 Montpellier Cedex 05, Rue de la Cardonille

来源：

BIOCHIMIE | 1994年 / 76卷 / 3-4期

关键词：

GLUCAGON; MINIGLUCAGON; EXTRACELLULAR PROCESSING; 100-KDA PROTEASE;

D O I：

10.1016/0300-9084(94)90161-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucagon is secondarily processed into its C-terminal (19-29) fragment, referred to as 'miniglucagon', which modulates the glucagon action. This extracellular processing, occurring at the level of the glucagon target cells, is due to the presence at the cell surface of a new 100-kDa processing enzyme with characteristics of both thiol- and metalloprotease.

引用

页码：295 / 299

页数：5

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