SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED STEREOSPECIFIC ANALOGS OF GLUTAMIC-ACID AS ANTAGONISTS OF METABOTROPIC RECEPTORS

被引：19

作者：

TELLIER, F

ACHER, F

BRABET, I

PIN, JP

BOCKAERT, J

AZERAD, R

机构：

[1] UNIV PARIS 05,CHIM & BIOCHIM PHARMACOL & TOXICOL LAB,CNRS,U400,F-75270 PARIS 06,FRANCE

[2] CNRS,INSERM,CTR PHARMACOL ENDOCRINOL,UPR 9023,F-34094 MONTPELLIER 5,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 22期

关键词：

D O I：

10.1016/0960-894X(95)00457-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rigid analogs of ACPD have been synthesized to mimick different potential conformations of ACPD in aqueous solution. One of them, (+/-)-ABHD-I is a competitive antagonist at mGluR1a receptor with a K-B value of 300 mu M.

引用

页码：2627 / 2632

页数：6

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