JOINT EFFECTS OF MONOMER AND STABILIZER CONCENTRATIONS ON PHYSICOCHEMICAL CHARACTERISTICS OF POLY(BUTYL 2-CYANOACRYLATE) NANOPARTICLES

被引：22

作者：

ALONSO, MJ

SANCHEZ, A

TORRES, D

SEIJO, B

VILAJATO, JL

机构：

[1] Laboratorio de Farmacia Galénica Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de, Compostela

来源：

JOURNAL OF MICROENCAPSULATION | 1990年 / 7卷 / 04期

关键词：

D O I：

10.3109/02652049009040475

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A rotatable central composite design was applied to the formulation of poly(butyl 2-cyanoacrylate) nanoparticles with the aim of modifying some physico-chemical properties of these carriers in a controlled way. The joint effect of stabilizer concentration and monomer concentration on the mean particle size, on the electrophoretic mobility and on the polymer molecular weight has been investigated. The results demonstrate that the particle size is only dependent on the stabilizer concentration, nevertheless the electrophoretic mobility and the molecular weight distribution were affected simultaneously by the monomer and the stabilizer concentrations. Moreover, using the response surface diagrams it is possible to deduce the experimental conditions to design particles with the desired properties. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：517 / 526

页数：10

共 13 条

[1] Cochran W.G., Cox G.M., Diseños experimentales, pp. 384-387, (1978)
[2] Coover H.W., McIntire J.M., Skeist I., Handbook of Adhesives, 2nd edn, (1977)
[3] Couvreur P., Polyalkylcyanoacrylates as colloidal drug carriers, Critical Reviews in Therapeutic Drug Carrier Systems (C.R.C.), 5, pp. 1-20, (1988)
[4] Couvreur P., Kante B., Roland M., Guiot P., Baudhuin P., Speiser P., Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties, Journal of Pharmacy and Pharmacology, 31, pp. 331-337, (1979)
[5] Davis S.S., Illum L., The targeting of drugs using polymeric microspheres, British Polymer Journal, 15, pp. 160-164, (1983)
[6] Douglas S.J., Illum L., Davis S.S., Kreuter J., Particle size and size distribution of poly(butyl-2-cyanoacrylate) nanoparticles I. Influence of physicochem-ical factors, Journal of Colloid and Interface Science, 101, pp. 149-158, (1984)
[7] Douglas S.J., Illum L., Davis S.S., Particle size and size distribution of poly(butyl-2-cyanoacrylate) nanoparticles II. Influence of stabilizers, Journal of Colloid and Interface Science, 103, pp. 154-163, (1985)
[8] Douglas S.J., Illum L., Davis S.S., Poly(butyl-2-cyanoacrylate) nanoparticles with differing surface charges, Journal of Controlled Rellease, 3, pp. 15-23, (1986)
[9] El-Egakey M.A., Bentele V., Kreuter J., Molecular Weights of polycyanoacrylate nanoparticles, International Journal of Pharmaceutics, 13, pp. 349-352, (1983)
[10] Henry-Michelland S., Alonso M.J., Andremont A., Maincent P., Sauzieres S.J., Couvreur P., Attachment of antibiotics to nanoparticles: preparation, drug-release and antimicrobial activity, In Vitro. International Journal of Pharmaceutics, 35, pp. 121-127, (1987)

← 1 2 →