ENDOTHELIN-1 RELEASE FROM THE MESENTERIC-ARTERIES OF CYCLOSPORINE-TREATED RATS

被引：22

作者：

TAKEDA, Y

MIYAMORI, I

YONEDA, T

TAKEDA, R

机构：

[1] Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 213卷 / 03期

关键词：

ENDOTHELIN-1; CYCLOSPORINE; HYPERTENSION; MESENTERIC ARTERY; BLOOD PRESSURE;

D O I：

10.1016/0014-2999(92)90635-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The release of endothelin-1 from mesenteric arteries from cyclosporine-treated rats was measured by a specific enzyme immunoassay after purification of the perfusate on an immunoaffinity column. Mesenteric arteries from cyclosporine-treated rats (25 mg/kg per day for 6 weeks) released a significantly larger amount of endothelin-1 than arteries from vehicle-treated control rats (P < 0.05). Serum creatinine levels were not significantly different in the two groups. These findings indicate that cyclosporine is a potential inducer of endothelin release from the mesenteric artery.

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收藏

页码：445 / 447

页数：3

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