ENHANCED DISSOLUTION AND ABSORPTION OF TRIMETHOPRIM FROM COPRECIPITATES WITH POLYETHYLENE GLYCOLS AND POLYVINYLPYRROLIDONE

被引：13

作者：

GUPTA, RL

KUMAR, R

SINGLA, AK

机构：

[1] Department of Pharmaceutical Sciences, Panjab University, Chandigarh

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 03期

关键词：

D O I：

10.3109/03639049109043840

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Coprecipitates of trimethoprim have been prepared by solvent method using polyethylene glycols 4000, 6000 and 9000, and polyvinylpyrrolidone (M.W. 40,000) as water soluble carriers. A marked increase in the dissolution rate of trimethoprim in the coprecipitates was observed compared with that of the drug alone. Coprecipitates with polyethylene glycol 6000 (1:2) showed faster release as well as bioavailability of the drug in human volunteers.

引用

页码：463 / 468

页数：6

共 8 条

[1] TRIMETHOPRIM A SULPHONAMIDE POTENTIATOR [J].