NEUROCHEMICAL EFFECTS OF CHRONIC COADMINISTRATION OF RITANSERIN AND HALOPERIDOL - COMPARISON WITH CLOZAPINE EFFECTS

被引:19
作者
LAPPALAINEN, J
HIETALA, J
KOULU, M
SYVALAHTI, E
机构
[1] Department of Pharmacology, University of Turku, Turku
关键词
5-HT; (5-hydroxytryptamine; serotonin); Clozapine; Dopamine; Haloperidol; Neuroleptics; Ritanserin;
D O I
10.1016/0014-2999(90)94206-D
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of chronic treatment with clozapine (20 mg/kg per day), ritanserin (0.5 mg/kg per day), haloperidol (0.5 mg/kg per day), or the combination of haloperidol and ritanserin, on dopamine (DA) and serotonin (5-HT) metabolism were studied. Chronic haloperidol treatment decreased DA metabolism in nucleus caudatus. Chronic ritanserin treatment failed to alter striatal or mesolimbic DA metabolism but decreased the concentrations of 5-HT and 5-hydroxyindoleacetic acid in the nucleus raphe dorsalis. The effects of chronic haloperidol were not altered by concomitant ritanserin administration. In comparison, chronic clozapine treatment affected neither DA nor 5-HT metabolism. These results show that the biochemical effects of chronic haloperidol treatment on the major ascending DA neurons cannot be modulated by concomitant 5-HT2 receptor blockade. © 1990.
引用
收藏
页码:403 / 407
页数:5
相关论文
共 10 条