ELECTRICALLY CONTROLLED DRUG DELIVERY SYSTEM USING POLYELECTROLYTE GELS

被引:106
作者
SAWAHATA, K
HARA, M
YASUNAGA, H
OSADA, Y
机构
[1] Department of Chemistry, Ibaraki University, Mito
关键词
POLYELECTROLYTE GELS; INSULIN; DRY DELIVERY SYSTEM; CHEMOMECHANICAL SYSTEM; ARTIFICIAL MUSCLE;
D O I
10.1016/0168-3659(90)90165-P
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Electrically stimulated drug delivery systems using polyelectrolyte gel and microparticles are experimentally demonstrated. The principle of the systems is based on the chemomechanical shrinking and swelling of polymer gels under an electric field. It was found that bioactive materials, such as pilocarpine hydrochloride, glucose and insulin, are successfully released from the gel by switching the electric field alternately on and off. The release mechanism of these compounds is briefly discussed.
引用
收藏
页码:253 / 262
页数:10
相关论文
共 19 条
[1]  
Trubetskoy, Berdichevsky, Efremov, Torchilin, On the possibility of the unification of drug targeting systems, Biochem. Pharmacol., 36, pp. 839-842, (1987)
[2]  
Jeong, Kim, Eenink, Feijen, Self-regulating insulin delivery systems I Synthesis and characterization of glycosylated insulin, Journal of Controlled Release, 1, pp. 57-66, (1984)
[3]  
Sato, Jeong, McRea, Kim, Self-regulating insulin delivery systems II In vitro Studies, Journal of Controlled Release, 1, pp. 67-77, (1984)
[4]  
Jeong, Kim, Holmberg, McRea, Self-regulating insulin delivery systems III In vivo studies, Journal of Controlled Release, 2, pp. 143-152, (1985)
[5]  
Hoffman, Application of thermally reversible polymers and hydrogels in therapeutics and diagnostics, J. Controlled Release, 6, pp. 297-305, (1987)
[6]  
Dong, Hoffman, Sadurni, pH sensitive hydrogels based on thermally reversible gels for enteric drug delivery, Proc. Int. Symp. Controlled Release Bioact. Mater., 16th, pp. 95-96, (1989)
[7]  
Bae, Okano, Hsu, Kim, Thermosensitive polymers as on-off switches for drug release, Die Makromolekulare Chemie, Rapid Communications, 8, pp. 481-485, (1987)
[8]  
Siegel, Falamarzian, Firestone, Moxley, pH-controlled release from hydrophobic/polyelectrolyte copolymer hydrogels, J. Controlled Release, 8, pp. 179-182, (1988)
[9]  
Kost, Horbett, Ratner, Singh, Glucose-sensitive membranes containing glucose oxidase: activity, swelling, and permeability studies, J. Biomed. Mater. Res., 19, pp. 1117-1133, (1984)
[10]  
Albin, Horbett, Ratner, Glucose sensitive membranes for controlled delivery of insulin: insulin transport studies, J. Controlled Release, 2, pp. 153-164, (1985)