A SEARCH FOR BORDETELLA-PERTUSSIS INFECTION IN UNIVERSITY-STUDENTS

被引:210
作者
MINK, CM
CHERRY, JD
CHRISTENSON, P
LEWIS, K
PINEDA, E
SHLIAN, D
DAWSON, JA
BLUMBERG, DA
机构
[1] UNIV CALIF LOS ANGELES,MED CTR,SCH MED,DEPT PEDIAT,10833 LECONTE AVE,MDCC 22-442,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,MED CTR,DEPT BIOMATH,LOS ANGELES,CA 90024
[3] UNIV CALIF LOS ANGELES,MED CTR,STUDENT HLTH SERV,LOS ANGELES,CA 90024
关键词
D O I
10.1093/clinids/14.2.464
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
University students with persistent cough of greater-than-or-equal-to 6 days' duration were evaluated for evidence of infection with Bordetella pertussis. Of 130 students studied during a 30-month period, 34 (26%) were found to have evidence of recent infections with B. pertussis. Infection was identified by direct fluorescent antibody assay of a nasopharyngeal specimen in one student and serologically in 33 additional subjects. B. pertussis was not recovered on culture of nasopharyngeal specimens from any subjects. Students with B. pertussis infection were identified in seven of the eight 3-month periods in which students were enrolled during the 30-month investigation, suggesting an endemic rather than epidemic pattern of infection in this university population. Illnesses of students with pertussis were similar to the illnesses of students without pertussis. The findings in this study suggest that adult populations in which endemic illness occurs at a relatively constant rate may be the reservoirs for pertussis outbreaks in susceptible children. Immunization programs in the future will need to employ booster doses for adults if complete control of B. pertussis infection is our goal.
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收藏
页码:464 / 471
页数:8
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