GENOTOXICITY OF THE FUNGICIDE DICHLOFLUANID IN 7 ASSAYS

被引：8

作者：

HEIL, J ^{[1
]}

REIFFERSCHEID, G ^{[1
]}

HELLMICH, D ^{[1
]}

HERGENRODER, M ^{[1
]}

ZAHN, RK ^{[1
]}

机构：

[1] ACAD SCI & LITERATURE,W-6500 MAINZ,GERMANY

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1991年 / 17卷 / 01期

关键词：

DNA ALTERATION; PESTICIDES; SHORT-TERM TESTS; MUTAGENICITY; CARCINOGENICITY;

D O I：

10.1002/em.2850170104

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Seven different endpoints for detection of genotoxicity have been used to demonstrate the DNA-altering properties of Dichlofluanid, a fungicide commonly used in viticulture pest control. Each endpoint (DNA synthesis inhibition test, alkaline visosimetry, umu-test, alkaline filter elution, FADU-test, P-32-postlabeling, and electron microscopy) shows clear evidence of genotoxicity. These data indicate that application of the fungicide dichlofluanid may be mutagenic and/or carcinogenic for exposed humans.

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页码：20 / 26

页数：7

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