LARGEST SUBUNIT OF DROSOPHILA TRANSCRIPTION FACTOR-IID DIRECTS ASSEMBLY OF A COMPLEX CONTAINING TBP AND A COACTIVATOR

被引：165

作者：

WEINZIERL, ROJ

DYNLACHT, BD

TJIAN, R

机构：

[1] Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley

[2] Massachusetts General Hospital, Cancer Center, Charlestown

来源：

NATURE | 1993年 / 362卷 / 6420期

关键词：

D O I：

10.1038/362511a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The TFIID complex consists of the TATA-binding protein (TBP) and associated factors (TAFs) serving to mediate transcriptional activation by promoter-specific regulators. Here we report the cloning of Drosophila TAF(II)250 and the assembly of a partial complex containing recombinant TBP, TAF(II)110 and the C-terminal domain of TAF(II)250. This triple complex supports Sp1 activation and reveals specific interactions between TAF(II)250, TBP and TAF(II)110.

引用

页码：511 / 517

页数：7

共 31 条

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