APOE EPSILON-4 ALLELIC ASSOCIATION WITH ALZHEIMERS-DISEASE - INDEPENDENT CONFIRMATION USING DENATURING GRADIENT GEL-ELECTROPHORESIS

被引：69

作者：

PEACOCK, ML ^{[1
]}

FINK, JK ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI

来源：

NEUROLOGY | 1994年 / 44卷 / 02期

关键词：

D O I：

10.1212/WNL.44.2.339

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is intriguing evidence-associating apolipoprotein E (ApoE) with Alzheimer's disease (AD). ApoE is deposited with beta-amyloid in senile plaques and binds to p-amyloid in vitro. We used denaturing gradient gel electrophoresis to identify ApoE epsilon 2, epsilon 3, and epsilon 4 alleles in 135 control subjects and 57 AD patients. We observed a marked increase in ApoE epsilon 4 allele frequency (0.40) in AD patients compared with control subjects (0.14) (p < 0.0001). Our independent finding of a marked association of ApoE epsilon 4 allele with AD further supports a possible role of ApoE in the pathogenesis of AD and confirms the study of Saunders et al (Neurology 1993;43:1467-1472).

引用

页码：339 / 341

页数：3

共 10 条

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