ANALYSES OF VOLATILE C-2 HALOETHANES AND HALOETHENES IN TISSUES - SAMPLE PREPARATION AND EXTRACTION

被引：18

作者：

CHEN, XM ^{[1
]}

DALLAS, CE ^{[1
]}

MURALIDHARA, S ^{[1
]}

SRIVATSAN, V ^{[1
]}

BRUCKNER, JV ^{[1
]}

机构：

[1] UNIV GEORGIA,COLL PHARM,DEPT PHARMACOL & TOXICOL,ATHENS,GA 30602

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 612卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80164-Y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A tissue extraction procedure was developed which minimized loss of readily volatilizable compounds for subsequent quantification by headspace gas chromatography, and evaluated for perchloroethylene (PER), 1,1,1-trichloroethane, 1, 1,2,2-tetrachloroethane, and 1, 1,2-trichloroethylene. Of the procedures evaluated, joint isooctane and saline tissue homogenization had the most efficient recovery, ranging from 73 to 104% for the four halocarbons from seven different rat tissues. PER concentrations were also determined in tissues of rats following in vivo halocarbon administration. Recovery did not appear to be tissue-dependent, but did vary somewhat with test chemical, with the least volatile, most lipophilic compounds exhibiting the highest recovery.

引用

页码：199 / 208

页数：10

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