CELL TYPE-DEPENDENCE FOR VPU FUNCTION

被引：46

作者：

GERAGHTY, RJ

TALBOT, KJ

CALLAHAN, M

HARPER, W

PANGANIBAN, AT

机构：

[1] UNIV WISCONSIN,MCARDLE LAB CANC RES,1400 UNIV AVE,MADISON,WI 53706

[2] BAYLOR COLL MED,DEPT BIOCHEM,HOUSTON,TX 77030

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 2-3期

关键词：

RETROVIRUS; VIRUS RELEASE; YEAST; FUSION PROTEIN;

D O I：

10.1111/j.1600-0684.1994.tb00115.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Human immunodeficiency virus type 1 Vpu has been shown to facilitate virus release from HeLa cells. We demonstrated that Vpu expression is not required for efficient virus release from Cos 1 and CV-1 cells. A yeast GAL4 transcriptional activation system was used to screen for cellular proteins that may interact with Vpu. One such protein was identified which we provisionally designate ''Vpu interactive protein'' or VIP.

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页码：146 / 150

页数：5

相关论文

共 24 条

[1] HIGH-EFFICIENCY TRANSFORMATION OF MAMMALIAN-CELLS BY PLASMID DNA [J].

CHEN, C ;

OKAYAMA, H .

MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (08) :2745-2752

[2] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VPU PROTEIN INDUCES DEGRADATION OF CD4 INVITRO - THE CYTOPLASMIC DOMAIN OF CD4 CONTRIBUTES TO VPU SENSITIVITY [J].

CHEN, MY ;

MALDARELLI, F ;

KARCZEWSKI, MK ;

WILLEY, RL ;

STREBEL, K .

JOURNAL OF VIROLOGY, 1993, 67 (07) :3877-3884

[3] IDENTIFICATION OF A PROTEIN ENCODED BY THE VPU GENE OF HIV-1 [J].

COHEN, EA ;

TERWILLIGER, EF ;

SODROSKI, JG ;

HASELTINE, WA .

NATURE, 1988, 334 (6182) :532-534

[4]

CULLEN BR, 1987, METHOD ENZYMOL, V152, P684

[5] ANALYSIS OF HIV-1 ENVELOPE MUTANTS AND PSEUDOTYPING OF REPLICATION-DEFECTIVE HIV-1 VECTORS BY GENETIC COMPLEMENTATION [J].

DELWART, EL ;

BUCHSCHACHER, GL ;

FREED, EO ;

PANGANIBAN, AT .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (09) :1669-1677

[6] THE RETINOBLASTOMA PROTEIN ASSOCIATES WITH THE PROTEIN PHOSPHATASE TYPE-1 CATALYTIC SUBUNIT [J].

DURFEE, T ;

BECHERER, K ;

CHEN, PL ;

YEH, SH ;

YANG, YZ ;

KILBURN, AE ;

LEE, WH ;

ELLEDGE, SJ .

GENES & DEVELOPMENT, 1993, 7 (04) :555-569

[7] A MUTATION IN THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TRANSMEMBRANE GLYCOPROTEIN-GP41 DOMINANTLY INTERFERES WITH FUSION AND INFECTIVITY [J].

FREED, EO ;

DELWART, EL ;

BUCHSCHACHER, GL ;

PANGANIBAN, AT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) :70-74

[8] MUTATIONAL ANALYSIS OF THE CLEAVAGE SEQUENCE OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN PRECURSOR-GP160 [J].

FREED, EO ;

MYERS, DJ ;

RISSER, R .

JOURNAL OF VIROLOGY, 1989, 63 (11) :4670-4675

[9] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VPU HAS A CD4-GLYCOPROTEIN AND AN ENVELOPE GLYCOPROTEIN-INDEPENDENT FUNCTION [J].

GERAGHTY, RJ ;

PANGANIBAN, AT .

JOURNAL OF VIROLOGY, 1993, 67 (07) :4190-4194

[10] VPU PROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENHANCES THE RELEASE OF CAPSIDS PRODUCED BY GAG GENE CONSTRUCTS OF WIDELY DIVERGENT RETROVIRUSES [J].

GOTTLINGER, HG ;

DORFMAN, T ;

COHEN, EA ;

HASELTINE, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :7381-7385