ROLES OF THE NMDA AND QUISQUALATE KAINATE RECEPTORS IN THE INDUCTION AND EXPRESSION OF KINDLED BURSTS IN RAT HIPPOCAMPAL SLICES

被引：8

作者：

BAWIN, SM

SATMARY, WM

ADEY, WR

机构：

[1] LOMA LINDA UNIV,DEPT PHYSIOL,LOMA LINDA,CA 92350

[2] LOMA LINDA UNIV,DEPT SURG,LOMA LINDA,CA 92350

[3] LOMA LINDA UNIV,DEPT NEUROSURG,LOMA LINDA,CA 92350

来源：

EPILEPSY RESEARCH | 1993年 / 15卷 / 01期

关键词：

HIPPOCAMPAL SLICES; KINDLING; INDUCTION AND EXPRESSION OF INTERICTAL BURSTS; EPILEPSY; GLUTAMATE RECEPTORS;

D O I：

10.1016/0920-1211(93)90003-P

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We used combinations of NMDA and quisqualate/kainate (Q/K) receptor antagonists and low Mg2+ (0.1 mM) solutions to study the respective roles of these receptors during in vitro kindling of interictal bursts in the CA3 area of rat hippocampal slices. Intracellular and extracellular recordings in CA3 showed that Q/K receptors were not necessary for the induction of kindling once the Mg2+ block of NMDA was alleviated, but that the expression of bursts kindled via NMDA-driven mechanisms was Q/K-dependent.

引用

页码：7 / 13

页数：7

共 23 条

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