BIOSYNTHESIS OF (+)-EPICUBENOL

被引：21

作者：

CANE, DE

TANDON, M

机构：

[1] Department of Chemistry, Brown University, Providence, RI 02912, Box H

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(00)73498-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Incubation of [6-H-2]FPP (14a) with epicubenol synthase isolated from Streptomyces sp. LL-B7 gave epicubenol (1c) labeled at D-9 as established by 2H NMR. These results confirm the involvement of a predicted 1,2-hydride shift in the mechanism of formation of 1.

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页码：5355 / 5358

页数：4

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