MALARIA - TOXINS, CYTOKINES AND DISEASE

被引：58

作者：

JAKOBSEN, PH

BATE, CAW

TAVERNE, J

PLAYFAIR, JHL

机构：

[1] UCL, SCH MED, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND

[2] UNIV COPENHAGEN HOSP, CTR MED PARASITOL, DEPT INFECT DIS M7722, DK-2200 COPENHAGEN N, DENMARK

[3] JOHN RADCLIFFE HOSP, INST MOLEC MED, DEPT PAEDIAT, OXFORD OX3 9DU, ENGLAND

来源：

PARASITE IMMUNOLOGY | 1995年 / 17卷 / 05期

关键词：

MALARIA; TOXINS; CYTOKINES; TNF; PHOSPHOLIPIDS; PATHOLOGY;

D O I：

10.1111/j.1365-3024.1995.tb01019.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this review the old concept of severe malaria as a toxic disease is re-examined in the light of recent discoveries in the field of cytokines. Animal studies suggest that the induction of TNF by parasite-derived molecules may be partly responsible for cerebral malaria and anaemia, while hypoglycaemia may be due to direct effects of similar molecules on glucose metabolism. These molecules appear to be phospholipids and we suggest that when fully characterized they might form the basis of antitoxic therapy for malaria.

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页码：223 / 231

页数：9

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