STEREOSELECTIVE 1ST-PASS METABOLISM OF HIGHLY CLEARED DRUGS - STUDIES OF THE BIOAVAILABILITY OF L-VERAPAMIL AND D-VERAPAMIL EXAMINED WITH A STABLE ISOTOPE TECHNIQUE

被引:186
作者
VOGELGESANG, B
ECHIZEN, H
SCHMIDT, E
EICHELBAUM, M
机构
关键词
D O I
10.1111/j.1365-2125.1984.tb02536.x
中图分类号
R9 [药学];
学科分类号
1007 ;
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页码:733 / 740
页数:8
相关论文
共 22 条
[1]   CLINICAL PHARMACOKINETICS OF VERAPAMIL IN PATIENTS WITH ATRIAL-FIBRILLATION [J].
ANDERSON, P ;
BONDESSON, U ;
SYLVEN, C .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 23 (01) :49-57
[2]   BIOLOGICAL PROPERTIES OF OPTICAL ISOMERS OF PROPRANOLOL AND THEIR EFFECTS ON CARDIAC ARRHYTHMIAS [J].
BARRETT, AM ;
CULLUM, VA .
BRITISH JOURNAL OF PHARMACOLOGY, 1968, 34 (01) :43-+
[3]   PHARMACOKINETICS OF (+)-VERAPAMIL, (-)-VERAPAMIL AND (+/-)-VERAPAMIL AFTER INTRAVENOUS ADMINISTRATION [J].
EICHELBAUM, M ;
MIKUS, G ;
VOGELGESANG, B .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 17 (04) :453-458
[4]   INTER-SUBJECT AND INTRA-SUBJECT VARIATION IN THE 1ST-PASS ELIMINATION OF HIGHLY CLEARED DRUGS DURING CHRONIC DOSING - STUDIES WITH DEUTERATED VERAPAMIL [J].
EICHELBAUM, M ;
SOMOGYI, A .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 26 (01) :47-53
[5]  
EICHELBAUM M, 1979, DRUG METAB DISPOS, V7, P145
[6]   SUPERIORITY OF STABLE ISOTOPE TECHNIQUES IN THE ASSESSMENT OF THE BIOAVAILABILITY OF DRUGS UNDERGOING EXTENSIVE 1ST PASS ELIMINATION - STUDIES OF THE RELATIVE BIOAVAILABILITY OF VERAPAMIL TABLETS [J].
EICHELBAUM, M ;
DENGLER, HJ ;
SOMOGYI, A ;
VONUNRUH, GE .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 19 (02) :127-131
[7]   EFFECTS OF VERAPAMIL ON P-R-INTERVALS IN RELATION TO VERAPAMIL PLASMA-LEVELS FOLLOWING SINGLE IV AND ORAL-ADMINISTRATION AND DURING CHRONIC TREATMENT [J].
EICHELBAUM, M ;
BIRKEL, P ;
GRUBE, E ;
GUTGEMANN, U ;
SOMOGYI, A .
KLINISCHE WOCHENSCHRIFT, 1980, 58 (18) :919-925
[8]  
EICHELBAUM M, 1981, EUR J CLIN PHARMACOL, V19, P131
[9]   VERAPAMIL KINETICS IN NORMAL SUBJECTS AND PATIENTS WITH CORONARY-ARTERY SPASM [J].
FREEDMAN, SB ;
RICHMOND, DR ;
ASHLEY, JJ ;
KELLY, DT .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 30 (05) :644-652
[10]   VERAPAMIL DISPOSITION KINETICS IN CHRONIC ATRIAL-FIBRILLATION [J].
KATES, RE ;
KEEFE, DLD ;
SCHWARTZ, J ;
HARAPAT, S ;
KIRSTEN, EB ;
HARRISON, DC .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 30 (01) :44-51