EFFLUX OF CHLORIDE FROM LACTATING RAT MAMMARY TISSUE-SLICES

被引:8
作者
SHENNAN, DB
MCNEILLIE, SA
机构
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1990年 / 95卷 / 03期
关键词
D O I
10.1016/0300-9629(90)90234-J
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1. 1. The efflux of chloride (using 36Cl) from lactating rat mammary tissue slices has been investigated. 2. 2. Chloride efflux was found to be temperature dependent; lowering the temperature of the incubation medium reduced the fractional efflux. 3. 3. The stilbene derivatives DIDS was without effect on the fractional release of Cl when studied at 20°C. However, DIDS was found to attenuate the increase in efflux found upon transferring the tissue from a medium maintained at 4°C to one at 20°C. 4. 4. The loop-diuretic furosemide, also reduced the temperature-sensitive portion of Cl efflux. 5. 5. Chloride efflux was transiently increased when tissue slices were transferred from a medium containing gluconate as the principal anion to one containing Cl. 6. 6. The results appear to confirm that mammary Cl transport is mediated via anion exchange and via (Na + K + Cl) cotransport. © 1990.
引用
收藏
页码:367 / 371
页数:5
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