GELATION OF LIPOSOME INTERIOR - A NOVEL METHOD FOR DRUG ENCAPSULATION

被引：217

作者：

LASIC, DD

FREDERIK, PM

STUART, MCA

BARENHOLZ, Y

MCINTOSH, TJ

机构：

[1] UNIV LIMBURG,DEPT PATHOL,6200 MD MAASTRICHT,NETHERLANDS

[2] HEBREW UNIV JERUSALEM,DEPT BIOCHEM,JERUSALEM,ISRAEL

[3] DUKE UNIV,DEPT CELL BIOL,DURHAM,NC 27706

来源：

FEBS LETTERS | 1992年 / 312卷 / 2-3期

关键词：

LIPOSOME; DRUG LOADING; (NH4)2SO4 GRADIENT; DOXORUBICIN; GEL;

D O I：

10.1016/0014-5793(92)80947-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liposomes can be loaded with weak acids and bases, which exist in solutions in equilibrium with membrane permeable uncharged form, using various gradients across their membranes. Because in some cases the estimated drug concentration in the loaded liposomes exceeds their aqueous solubility we investigated the physical state of the liposome encapsulated anticancer drug Doxorubicin. X-Ray diffraction, electron microscopy, and test tube solubility experiments have shown that upon encapsulation the drug molecules form a gel-like phase

引用

页码：255 / 258

页数：4

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