PROTOTYPICAL HTLV-I/II INFECTION IS RARE IN LGL LEUKEMIA

被引:38
作者
LOUGHRAN, TP
SHERMAN, MP
RUSCETTI, FW
FREY, S
COYLE, T
MONTAGNA, RA
JONES, B
STARKEBAUM, G
POIESZ, BJ
机构
[1] SUNY HLTH SCI CTR, DEPT MED, SYRACUSE, NY USA
[2] SUNY HLTH SCI CTR, DEPT MICROBIOL, SYRACUSE, NY USA
[3] SUNY HLTH SCI CTR, DEPT IMMUNOL, SYRACUSE, NY USA
[4] UNIV WASHINGTON, SCH MED, VET AFFAIRS MED CTR, SEATTLE, WA USA
[5] UNIV WASHINGTON, SCH MED, DEPT MED, SEATTLE, WA USA
[6] CELLULAR PROD INC, BUFFALO, NY USA
[7] FREDERICK CANC RES FACIL, FREDERICK, MD USA
关键词
LGL LEUKEMIA; HTLV-I/II; GAG P24; ENV P21E; PCR; ELISA;
D O I
10.1016/0145-2126(94)90078-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The etiology of LGL leukemia is not known; however, we recently detected HTLV-II in a patient with LGL leukemia. In this study, we found that sera from 6 of 28 patients with LGL leukemia were positive for HTLV-I/II using a whole virus ELISA; moreover, the ELISA-negative sera were near the positive cut-off value. Therefore, we performed additional studies on these sera using commercially available assays which can confirm and distinguish HTLV-I from HTLV-II infection. Serum from on ly one patient was confirmed positive using conventional criteria (HTLV-II+). Sera from 25 patients (89%) had indeterminate reactivity on Western blot assays. Of these, sera from 21 (84%) reacted to gag protein p24; 12 (48%) reacted with recombinant env protein p21e, and 10 (40%) reacted with both. We could not detect HTLV-I/ II pol or pX gene sequences in these patients using polymerase chain reaction analyses, with the exception of the HTLV-II-infected patient described previously. These data show that most patients with LGL leukemia are not infected with prototypical HTLV-I or HTLV-II. The frequent reactivity of patient sera to HTLV-I/II gag protein p24 and to env protein p21e, however, suggests that a deleted or variant farm of HTLV-I/II may be associated with LGL leukemia.
引用
收藏
页码:423 / 429
页数:7
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