3'-SUBSTITUTED PYRIMIDINES VIA ALKYLATION-OPENING OF 2,3'-CYCLOTHYMIDINE

被引：7

作者：

SAHA, AK

SCHAIRER, W

UPSON, DA

机构：

[1] Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Malvern, PA 19355

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(00)61346-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted thynidine derivatives are of interest because of their potential antiviral properties. We demonstrate a general strategy for synthesis of 3'-substituted thymidine derivatives, consisting of activation via N-3 alkylation of 2,3'-cyclothymidine followed by nucleophilic opening at the 3'-posidon. Examples include demonstration of carbon-carbon bond formation at the 3'-position.

引用

收藏

页码：8411 / 8414

页数：4

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