DEHYDROAMINO ACID-DERIVATIVES FROM D-ARABINOSE AND L-SERINE - SYNTHESIS OF MODELS FOR THE AZINOMYCIN ANTITUMOR ANTIBIOTICS

被引：54

作者：

MORAN, EJ ^{[1
]}

TELLEW, JE ^{[1
]}

ZHAO, ZC ^{[1
]}

ARMSTRONG, RW ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90024

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 27期

关键词：

D O I：

10.1021/jo00079a033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of aldehydes 17 from D-arabinose and 31 from L-serine provided key precursors for the generation of highly functionalized dehydroamino acid derivatives upon condensation with glycyl phosphonates. Subsequent bromination and intramolecular addition/elimination afforded the azabicyclo[3.1.0]hex-2-ylidene ring system postulated to exist in the azinomycin antitumor antibiotics.

引用

页码：7848 / 7859

页数：12

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